In most cases, AAPE ® is administered in combination with vitamin B1 (5 mg), vitamin B6 (2.5-5 mg), vitamin H (1 mg), vitamin C (80-100 mg), vitamin E (5 mg), coenzyme Q10 (10 U) and amino acids as nappage mesotherapy, in order to improve the function of mesotherapy with antioxidant effects and induce hair growth. A 31-gauge needle is used to inject a volume of roughly 0.02 ml into each injection site, which are spaced 1 cm apart (Fig. For a single treatment, 3-4 ml of AAPE ® is administered to the entire scalp using the papule injection (intradermal injection). The efficacy of hair regeneration therapy, as well as its side effects and safety, is thoroughly explained to each patient, and treatment is performed upon obtaining written consent. AAPE in comparison, contains more than 150 growth factors. PRP in the best condition, contain 10-15 growth factors. There is no anestetic required for the treatment. AAPE does not require any blood to be taken from you like PRP. The AAPE procedure is safer, easier, cleaner, non-invasive, painless, and cheaper. There is also the chance that you could have a negative reaction to the anesthetic used in the therapy. Injury to blood vessels or nerves, infection, calcification at the injection points, and scar tissue. Evidence for benefit is poor.”īecause PRP therapy involves injecting your own blood into your scalp, there carries a risk of side effects such as … Sometimes this approach is combined with other hair loss procedures or medications.Īccording to Wikipedia “Platelet-rich plasma, also known as autologous conditioned plasma, is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. PRP (platelet-rich plasma) therapy for hair loss is a three-step medical treatment in which a patient’s blood is drawn, processed, and then injected into the scalp. We offer both treatments separately or together, alternating the treatments every two weeks in our AAPE + PRP treatment plan. Which is better for hair loss? Both therapies are good for male and female alopecia. We use a micro needling device and massage technique to allow the serum to penetrate into the scalp. The same method is used to administer the AAPE serum into the scalp. Androgenic alopecia, also known as Male Pattern Hair Loss (MPHL) and Female Pattern Hair Loss (FPHL) is a common, chronic hair loss disorder affecting both men and women.ĪAPE (Adipose-derived stem cells Proteins Extracts) is a mixture of refined growth factors extracted from human adipose to promote hair growth and scalp health using outstanding ingredients approved by US FDA and CFDA. Many patients have experienced great success with this in-clinic hair loss therapy. Platelet-rich plasma (PRP) has become a proven method for the treatment of androgenic alopecia. We apply the serum topically using a micro needling device and massage technique to allow the serum to penetrate into the scalp. Platelet-rich plasma (PRP) therapy for alopecia is a three-step medical treatment in which a patient’s blood is drawn, centrifuged, re-applied back onto the scalp. We offer both PRP and AAPE for hair loss. Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium – Hirotaro Fukuoka, MD, PhD, and Hirotaka Suga, MD, PhD. Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration. Papers related to ADSCs and hair on PubMed. Numerous research papers in the hair growth field using Adipose-Derived Stem Cells. The brand AAPE is approved by dermatologists and medical professionals from Korea, Japan and USA.Īdipose-derived stem cell-conditioned medium is rich in growth factors such as vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, and insulin-like growth factor 1. In Japan, over 200 clinics are using AAPE with a clinical hair program for hair regrowth. AAPE® is the first product based on stem cell described in SCI journals with clinical results in humans.Įxosomes from human adipose derived stem cells promote proliferation and migration of skin fibroblasts.ĪAPE has over 600,000 clinical treatments used by over 3,000 dermatologists in more than 30 countries worldwide.
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